恒河猴感染猪尾猴疟原虫后危象期免疫学研究

Studies on Immune Function in Crisis of the Rhesus Monkey with Plasmondium inui

通过观察恒河猴血传急性感染猪尾猴疟原虫的过程发现,对宿主切脾后,原虫血症迅速升高而达到一个血症高峰。随着幼稚红细胞的出现,虫血症急剧下降而出现危象期,外周血T淋巴细胞数量急剧增加;红细胞免疫功能升高,接种后宿主疟疾抗体出现较晚,切脾可使IFA抗体滴度暂时下降,在危象期前一天和危象期中TFA抗体滴度急剧升高。

The present paper is a report of the immunological studies of the rhesus monkey infected with Plasmodium inui. While splenectomy done after inoculation, the host appeared a higher parasitemia. Accopamying the apperance of reticulocytes in peripheral circulation, the parasitemia droped quickly to low level. This is "crisis". During the crisis, the number or T cell quickly increased remarkably, the immune function of red cells was enhanced, IFA titer was quickly increased.