绿柱虫γ-内酯二萜对兔主动脉条的扩张作用

Vasodilating Action of Clavirolide C on Isolated Rabbit Aortic Smooth Muscles

绿柱虫γ-内酯二萜(C)是来源于软珊瑚Clavularia viridis Quoy and Gaimard的一个新结构化合物,能对抗KCI,NE所致兔主动脉条的收缩;对KCI作用的IC_(50)为6.8±1.8μmol·L^(-1)。C的作用与内皮细胞有关,与Ach的松血管效应产生相互影响,不受消炎痛、酚妥拉明的影响,可使KCl、CaCl_2量效曲线右移,并压低最大反应,PD_2值分別为4.95,5.3。但C只能平行右移NE量效曲线,PA_2值为5.62,9μmol.L^(-1)C可抑制由NE引起的依内钙和依外钙收缩,抑制率分別达82.1±7.1％,37.2％。

Clavirolide C（C） is a new compound isolated from marine soft coral. it could inhibit the contraction induced by high K+, norepinephrine （NE） on the rabbit aortic strips; IC50 of C on high K+ is 6.8±1.8μmol·L-1. Effects of C on the aortic strips had to do with endothelium; C had influence each other with Ach, but not with indomethacin and phentolamime. C showed noncompetitive antagonism to KCl, CaCl,. PD, values were 4.95, 5.31 respectively, but C shifted NE dose-response curves to the right and didn’t decreased the maximal response, PAz value was 5.62. 9μmol·L-1 C obviously inhibited the two component of contraction evoked by NE in rabbit aortic strips, percent of inhibition was 82.1 ±7.1％,37.2％ respectively.