摘要
目的 初步探讨某些职业性内分泌干扰物 (EDCs)与女工妇科肿瘤发生的相关性。方法 选择使用EDCs物质作为增塑剂、农药载体或制造杀虫 (菌 )剂、医用器具、绝缘电缆等多个工厂中接触EDCs的女性共 84 3人 ,进行问卷调查。结果 在 84 3例被调查者中发现妇科肿瘤患 2 5例 (2 97% ) ,其中乳腺癌发生率为 35 6 / 10万 ,卵巢癌发生率为 35 6 /10万 ,与一般人群乳腺癌发生率 (42 8/ 10万 )和卵巢癌发生率 (8 7/ 10万 )相比较均有显著增高 (P <0 0 5 ) ;同时 ,EDCs所致妇科肿瘤与其浓度高低似有关 ,接触 10年以上者肿瘤发生率显著高于接触 10年以下者 (P <0 0 5 )。结论 此次调查的职业性内分泌干扰物可能致妇科肿瘤 ,尤其乳腺癌和卵巢癌发生率增高 ,提示有必要作进一步深入研究。
Objective To study the relationship between endocrine disruptors and female reproductive tumors development.Methods The study was carried out with 843 female workers exposed to endocrine disruptors in some plants including plastic,chemical,paint and pharmaceutical et.al.Results The prevalence rate of female reproductive tumors was 2.97%,among them the breast cancer was 356/100 000 and ovarian cancer was also 356/100 000.The prevalence rates of breast cancer and Ovarian cancer in study workers were significantly higher than that in common group(P<0 05).The prevalence rate of female reproductive tumors in older workers employed over 10 years was significantly higher than that in young workers employed under 10 years (P<0 05).Conclusion It seemed that endocrine disruptors may cause female reproductive tumors,especially may raise the prevalence rate of breast cancer and ovarian cancer,indicating the need to further study.
出处
《职业卫生与病伤》
2002年第3期168-168,共1页
Occupational Health and Damage
基金
国家自然科学基金重点项目 (批准号 30 0 30 1 2 0 )
