摘要
对大庆市龙凤地区１００例Ｇｒａｖｅｓ病采用１：１配比的病例对照研究，分析形成Ｇｒａｖｅｓ病的危险因素．结果表明其危险因素有家族遗传史（ＯＲ＝１４３３．６４４０）；个性不稳定（ＯＲ＝２５．１３５３）；感染（Ｏ＝１３．７７３０）；生活事件（２）（ＯＲ＝３．３０３９），生活事件（３）（ＯＲ＝１１．１４５３）；初次怀孕年龄（ＯＲ＝１．１０９６）．没有发现因素间存在交互作用。结果说明Ｇｒａｖｅｓ病是一种受遗传因素和环境因素共同作用的自身免疫性疾病．从模型拟合的顺位、ＯＲ值大小及标准化回归系数上看，Ｇｒａｖｅｓ病受遗传因素影响较大。
We have analyzed the risk factors of Graves’disease by 1:1 matched case-control study.The results showed that the family hereditary history(OR=1433.6440); infection(OR=13.7730);Personality instability(OR=25.1353);life event(2)(OR=3.3039),life events(3)(OR=11.1453); first pregnancy age(OR=1.1096),were the risk factors of Graves’s disease.In addition,we have not found interaction between factors.The result indicated that Graves’disease was autimmune disease influenced by heriditary factors and environmental factors.But,Graves’disease was largely influenced by heriditary factors according to variable older,OR values and standard partial regression coefficient in mode fitting.
基金
黑龙江省卫生厅科研课题
