摘要
观察３０例ＨＢＶ、ＨＣＶ重叠感染患者血清病毒标志物的变化，并检测ＨＢＶ前Ｃ区１８９６位点突变发生率。结果发现：ＨＢＶ、ＨＣＶ重叠感染患者ＨＢｅＡｇ、ＨＢＶ、ＤＮＡ及ＨＣＶＲＮＡ阳性率明显低于单纯ＨＢＶ或ＨＣＶ感染患者；抗ＨＢｅ阳性率明显高于单纯ＨＢＶ感染者；ＨＢｓＡｇ、抗ＨＢｃＩｇＧ及抗ＨＣＶ平均几何滴度也较单纯感染者低，而ＨＢＶ前Ｃ区１８９６位点突变发生率却高于单纯ＨＢＶ感染患者。上述结果提示：ＨＢＶ、ＨＣＶ感染同一宿主时，存在相互干扰、抑制；ＨＢｅＡｇ的消失及抗－ＨＢｅ的阳转既与ＨＣＶ对ＨＢＶ复制的直接抑制有关，又与ＨＢＶ的前Ｃ区１８９６位点突变有关，且ＨＣＶ可能是导致ＨＢＶ前Ｃ区变异的原因之一。
The changes of sera viral marker of 30 patients with HBV and HCV superinfection were observed.Meanwhile,sera titers of HBsAg、anti HBc IgG、anti HCV and mutation of HBV precore region at 1896 were also investigated.The results showed that in superinfection positive rates of HBeAg、HBV DNA、HCV RNA and the average titers of HBsAg、anti HBc IgG、anti HCV were significant lower than those in single infection.Positive rate of anti HBe and incidence rate of mutation of HBV precore region at 1896 were higher in superinfection than those in single infection.The results suggested that interference existed between HBV and HCV,conversion from HBeAg to anti HBe was not only relative to the suppression of HCV but also to the mutation of HBV precore region,and HBV precore region mutation was probably due to action of HCV partialy.
