摘要
用哈尔滨市水源地江水的３种有机提取物（乙醚，丙酮和二氯甲烷）分别做ＮＩＨ３Ｔ３细胞转化试验结果表明：３种有机提取物各剂量组均能诱发该细胞出现典型的细胞转化灶，其细胞转化率呈现剂量反应关系。转化细胞的恶性表现是生长失去接触性抑制并能在软琼脂内生长。提示该江水可能具有潜在的致癌作用。
NIH3T3cell line was used for the study transformation induction by organic extract(ether,acetone and dichlormethance from water in the water source of Harbin city.The result indicated that malignant transformed foci were induced by three organic extracts mentioned above and the cellular transformation frequencies presented a dose response relationship and determination of malignant cells disappeared in restraining of contact and grew in culture of soft agar while control cells did not.Thus,the present study demonstrates that three organic extract from water in water source of Harbin city has potential carcinogenesis.
