静脉注射多巴胺对休克动物肾微循环血液灌流量的影响(激光多普勒血流计测定结果)

Effect of Dopamine on renal microcirculatory perfusion measured by a laser doppler flowmeter in shock animals

用激光多普勒微循环血流计研究了多巴胺对失血性休克大鼠(n=44)肾微循环血液灌流量的影响,结果发现20μg及40μg/0.1ml/100g体重静脉注射后5分钟,20分钟时肾灌流量均有明显增加,月龄低的大鼠比月龄高的大鼠反应更敏感。失血性休克家兔(n=17)静脉注射多巴胺后(100μg/1ml/kg体重)20分钟,肾皮质微循环血液灌流量明显增加,但是用电磁血流量计同步测定左肾动脉血流量,结果发现并无明显增加。根据上述结果,作者认为多巴胺增加肾皮质微循环血液灌流量的作用并不是通过肾血流量的增加,而可能是通过肾微循环内血液再分布实现的。

The effects of Dopamine on renal microcirculatory perfusion measured by a laser doppler flowmeter were studied in 44 hemorrhagic rats and 17 hemorrhagic rabbits. The results indi cated that at 5 and 20 min, after intravenous infusions of Dopamine(20ug or 40 ug/0.1 ml/100g B. W.) the renal perfusion signifcantly increased. The response to Dopamine was more sensitive in the young rats than that in the aged rats, 20 min, after intravenous infusion of Dopamine(100 μg/lml/lkg B. W.) the perfusion in renal cortex markedly increased. At same time it was found that the blood flow volume in left renal aetery no increased when it was measured by a square wave electromagnetic flowmeter. According to the results mentioned above, the author suggests that the mechanism of increase in renal microcirculation perfusion induced by Dopamine was probably related to the blood redistribution in renal microcirculation.