摘要
The proinflammatory cytokine interleukin-1 has been implicated in host suscep tibility to Helicobacter pylori -associated disease. Recent studies suggest tha t this susceptibility may be under genetic control. It remains to be determined whether the relationship between IL-1 gene polymorphism and gastrointestinal di sease in patients with H. pylori infection is due to the role of IL-1 in determ ining susceptibility to H. pylori infection per se or to the development of dist inct pathological lesions. The aim of this study was to prospectively investigat e the relationship between selected polymorphisms in three of the major IL-1 ge ne family members, seeking associations with H. pylori infection and/or gastric cancer. A total of 559 individuals were studied: 191 patients attending for gast roscopy, 98 with current or previous H. pylori, an additional 79 patients with g astric cancer, and 289 healthy controls. The major novel finding of the study wa s a marked difference in the genotype frequencies for the IL1R1 HinfI SNP in tho se with current or previous evidence of H. pylori compared to those without. (GG , 53 vs 75%; GA, 40 vs 19%; AA, 7 vs 6%; P = 0.0079). The association indicat es an increased risk of H. pylori infection or persistence in those with the IL1 R1 Hinf1 A allele (0.27 vs 0.156; P = 0.009; OR = 2.01). Our results suggest tha t the relationship among IL-1 gene polymorphism, H. pylori, and disease is more complex than initially proposed. More detailed studies of the IL-1 gene cluste r are needed.
The proinflammatory cytokine interleukin-1 has been implicated in host suscep tibility to Helicobacter pylori -associated disease. Recent studies suggest tha t this susceptibility may be under genetic control. It remains to be determined whether the relationship between IL-1 gene polymorphism and gastrointestinal di sease in patients with H. pylori infection is due to the role of IL-1 in determ ining susceptibility to H. pylori infection per se or to the development of dist inct pathological lesions. The aim of this study was to prospectively investigat e the relationship between selected polymorphisms in three of the major IL-1 ge ne family members, seeking associations with H. pylori infection and/or gastric cancer. A total of 559 individuals were studied: 191 patients attending for gast roscopy, 98 with current or previous H. pylori, an additional 79 patients with g astric cancer, and 289 healthy controls. The major novel finding of the study wa s a marked difference in the genotype frequencies for the IL1R1 HinfI SNP in tho se with current or previous evidence of H. pylori compared to those without. (GG , 53 vs 75%; GA, 40 vs 19%; AA, 7 vs 6%; P = 0.0079). The association indicat es an increased risk of H. pylori infection or persistence in those with the IL1 R1 Hinf1 A allele (0.27 vs 0.156; P = 0.009; OR = 2.01). Our results suggest tha t the relationship among IL-1 gene polymorphism, H. pylori, and disease is more complex than initially proposed. More detailed studies of the IL-1 gene cluste r are needed.
