摘要
Objectives The objective of this prospective study was to determine whether sociological and/or alcohol related behavioral factors could be predictive of relapse after orthotopic liver transplantation for alcoholic liver disease. Methods Fiftyfive liver transplanted patients out of a series of 120 alcoholic cirrhotic patients were enrolled in a randomized prospective study. This study was initially designed to compare the 2 year survival in intent to transplant patients versus in intent to use conventional treatment patients. For all patients, an identical questionnaire was completed at inclusion, and every 3 months for 5 years to collect data on alcohol related behavior factors. Results Fifty one patients fulfilled the criteria for the study. The mean follow up was 35.7 months (range: 1-86). Rate of alcohol relapse was 11%at one year and 30%at 2 years. Alcohol intake above 140 g a week was declared by 11%and 22%of patients at one and 2 years, respectively. The only variable leading to a significantly lower rate of relapse was abstinence for 6 months or more before liver transplantation (23%vs 79%, P = 0.0003). This variable was also significant for patients whose alcohol intake was greater than 140 g per week (P = 0.003) (adjusted relative risk =5.5; 95%CI = 1.3-24.5; P = 0.02). Multivariate analysis (Cox model) showed that abstinence for 6 months or more before liver transplantation was the unique predictive variable. Conclusion In this prospective study of 51 patients transplanted for alcoholic liver disease, abstinence before liver transplantation was the only predictive factor of alcohol relapse after liver transplantation.
Objectives The objective of this prospective study was to determine whether sociological and/or alcohol related behavioral factors could be predictive of relapse after orthotopic liver transplantation for alcoholic liver disease. Methods Fiftyfive liver transplanted patients out of a series of 120 alcoholic cirrhotic patients were enrolled in a randomized prospective study. This study was initially designed to compare the 2 year survival in intent to transplant patients versus in intent to use conventional treatment patients. For all patients, an identical questionnaire was completed at inclusion, and every 3 months for 5 years to collect data on alcohol related behavior factors. Results Fifty one patients fulfilled the criteria for the study. The mean follow up was 35.7 months (range: 1-86). Rate of alcohol relapse was 11%at one year and 30%at 2 years. Alcohol intake above 140 g a week was declared by 11%and 22%of patients at one and 2 years, respectively. The only variable leading to a significantly lower rate of relapse was abstinence for 6 months or more before liver transplantation (23%vs 79%, P = 0.0003). This variable was also significant for patients whose alcohol intake was greater than 140 g per week (P = 0.003) (adjusted relative risk =5.5; 95%CI = 1.3-24.5; P = 0.02). Multivariate analysis (Cox model) showed that abstinence for 6 months or more before liver transplantation was the unique predictive variable. Conclusion In this prospective study of 51 patients transplanted for alcoholic liver disease, abstinence before liver transplantation was the only predictive factor of alcohol relapse after liver transplantation.
