摘要
Although chemoembolization is known to be an effective palliative treatment i n hepatocellular carcinoma, it has a limited effect in large tumors. We report t he case of a patient with a large hepatocellular carcinoma of the left liver who had a significant and sustained clinical response after six sessions of chemoem bolization with a pirarubicin/amiodarone/lipiodol emulsion. Pirarubicin is an an thracycline which penetrates faster than doxorubicin into cancer cells. Amiodaro ne is a multidrug resistance inhibitor. Polysorbate 80, an excipient of injectab le amiodarone stabilizes the anthracycline/lipiodol emulsion. The clinical effic acy of this new formulation could be evaluated in a phase II clinical trial.
Although chemoembolization is known to be an effective palliative treatment i n hepatocellular carcinoma, it has a limited effect in large tumors. We report t he case of a patient with a large hepatocellular carcinoma of the left liver who had a significant and sustained clinical response after six sessions of chemoem bolization with a pirarubicin/amiodarone/lipiodol emulsion. Pirarubicin is an an thracycline which penetrates faster than doxorubicin into cancer cells. Amiodaro ne is a multidrug resistance inhibitor. Polysorbate 80, an excipient of injectab le amiodarone stabilizes the anthracycline/lipiodol emulsion. The clinical effic acy of this new formulation could be evaluated in a phase II clinical trial.
