摘要
Helicobacter pylori infection has a high prevalence in the elderly, but its ch aracteristics and treatment in the geriatric population are not well defined. Th e aims of the study were to characterize geriatric patients according to referra l patterns and results of the 13C-urea breath test ( 13C-UBT) and to investiga te the results of treatment combinations for H. pylori eradiction. The 13C-UBT was performed with 75 mg urea labeled with 13C. Physicians who ordered the test completed a questionnaire covering demographic data, indication for the test, ch ronic use of a proton pump inhibitor, or nonsteroidal anti-inflammatory drug, a nd type of eradiction therapy. The study sample consisted of 2128 patients, aged 70-102 years,958 (45%) men, referred for 13C-UBT. The test was positive on 6 97 (33%). His- tory of peptic disease was the main indication for referral, following by vali dation of successful eradication, Israeli origin screening for gastric cancer, t reatment with regimen containing metronidazole, history of peptic disease, and r ecurrence of symptoms were predictive factors for a positive 13C-UBT. Multivari ate logistic regression analysis revealed a significant influence of eradication therapy on negative results. History of peptic disease and validation of succes sful eradication are the main indications for referral of the elderly for 13C-U BT. Our results are in accordance with the increase in metronidazole resistance of H. pylori stains and the cohort effect of H. pylori infection on the elderly Israeli-born population.
Helicobacter pylori infection has a high prevalence in the elderly, but its ch aracteristics and treatment in the geriatric population are not well defined. Th e aims of the study were to characterize geriatric patients according to referra l patterns and results of the 13C-urea breath test ( 13C-UBT) and to investiga te the results of treatment combinations for H. pylori eradiction. The 13C-UBT was performed with 75 mg urea labeled with 13C. Physicians who ordered the test completed a questionnaire covering demographic data, indication for the test, ch ronic use of a proton pump inhibitor, or nonsteroidal anti-inflammatory drug, a nd type of eradiction therapy. The study sample consisted of 2128 patients, aged 70-102 years,958 (45%) men, referred for 13C-UBT. The test was positive on 6 97 (33%). His- tory of peptic disease was the main indication for referral, following by vali dation of successful eradication, Israeli origin screening for gastric cancer, t reatment with regimen containing metronidazole, history of peptic disease, and r ecurrence of symptoms were predictive factors for a positive 13C-UBT. Multivari ate logistic regression analysis revealed a significant influence of eradication therapy on negative results. History of peptic disease and validation of succes sful eradication are the main indications for referral of the elderly for 13C-U BT. Our results are in accordance with the increase in metronidazole resistance of H. pylori stains and the cohort effect of H. pylori infection on the elderly Israeli-born population.
