摘要
Background: The role of Helicobacter pylori in patients with cirrhosis and increased prevalence of peptic ulcers is still poorly defined. The objective is to evaluate the effect of H pylori eradication on ulcer recurrence in patients with cirrhosis. Methods: The study was conducted at a single, tertiary, referral hospital with 1200 beds. Patients with cirrhosis and duodenal ulcers were tested for H pylori and were enrolled in the study. Patients with positive H pylori received eradication therapy. Patients with duodenal ulcers received antisecretory therapy and regular endoscopic examinations. Main outcome measurements were the recurrence of duodenal ulcers within 1 year. Results: A total of 104 patients with cirrhosis and duodenal ulcers were enrolled. Fifty- four patients (52% ) were H pylori positive, and 50 patients (48% ) were H pylori negative. Forty- four patients received antimicrobial treatment and 36 patients achieved eradication of H pylori. Recurrent duodenal ulcers within 1 year were noted in 21 of 36 patients (58% ) who achieved H pylori eradication. Recurrent duodenal ulcers also were noted in 8 of the 18 patients (44% ) who remained H pylori positive and in 24 of the patients (48% ) who were H pylori negative since their enrollment in the study (p = 0.53). The limitation was a relatively small sample size. Conclusions: The results of our study showed that the prevalence of H pylori in patients with cirrhosis and duodenal ulcers was only 52% . Eradication of H pylori in patients with cirrhosis and duodenal ulcers did not effectively reduce the recurrence of ulcers.
Background: The role of Helicobacter pylori in patients with cirrhosis and increased prevalence of peptic ulcers is still poorly defined. The objective is to evaluate the effect of H pylori eradication on ulcer recurrence in patients with cirrhosis. Methods: The study was conducted at a single, tertiary, referral hospital with 1200 beds. Patients with cirrhosis and duodenal ulcers were tested for H pylori and were enrolled in the study. Patients with positive H pylori received eradication therapy. Patients with duodenal ulcers received antisecretory therapy and regular endoscopic examinations. Main outcome measurements were the recurrence of duodenal ulcers within 1 year. Results: A total of 104 patients with cirrhosis and duodenal ulcers were enrolled. Fifty- four patients (52% ) were H pylori positive, and 50 patients (48% ) were H pylori negative. Forty- four patients received antimicrobial treatment and 36 patients achieved eradication of H pylori. Recurrent duodenal ulcers within 1 year were noted in 21 of 36 patients (58% ) who achieved H pylori eradication. Recurrent duodenal ulcers also were noted in 8 of the 18 patients (44% ) who remained H pylori positive and in 24 of the patients (48% ) who were H pylori negative since their enrollment in the study (p = 0.53). The limitation was a relatively small sample size. Conclusions: The results of our study showed that the prevalence of H pylori in patients with cirrhosis and duodenal ulcers was only 52% . Eradication of H pylori in patients with cirrhosis and duodenal ulcers did not effectively reduce the recurrence of ulcers.
