摘要
In this study we aimed to determine the microorganisms found in perianal fistulas in Crohn’ s disease and whether treatment with ciprofloxacin affects these microorganisms. Thirteen patients (males/females, 7/6; median age, 34 years; range, 18- 61 years) with fistulas were treated with infliximab, 5 mg/kg intravenously, at weeks 6, 8, and 12 and randomized to double- blind treatment with ciprofloxacin, 500 mg bd (n = 6), or placebo (n = 7) for 12 weeks. Samples were taken at baseline and at weeks 6 and 18. In the ciprofloxacin group 10 different genera of microorganisms were identified, while 13 genera could be identified in the placebo group. Gram- negative enteric floras were present in a small minority. The genera found in patients with perianal fistulas were predominantly gram- positive microorganisms. Therefore, antimicrobial treatment should be directed toward these microorganisms.
In this study we aimed to determine the microorganisms found in perianal fistulas in Crohn' s disease and whether treatment with ciprofloxacin affects these microorganisms. Thirteen patients (males/females, 7/6; median age, 34 years; range, 18- 61 years) with fistulas were treated with infliximab, 5 mg/kg intravenously, at weeks 6, 8, and 12 and randomized to double- blind treatment with ciprofloxacin, 500 mg bd (n = 6), or placebo (n = 7) for 12 weeks. Samples were taken at baseline and at weeks 6 and 18. In the ciprofloxacin group 10 different genera of microorganisms were identified, while 13 genera could be identified in the placebo group. Gram- negative enteric floras were present in a small minority. The genera found in patients with perianal fistulas were predominantly gram- positive microorganisms. Therefore, antimicrobial treatment should be directed toward these microorganisms.
