A型肉毒杆菌毒素

Botulinum toxin as a cosmetic weapon

肉毒杆菌毒素是肉毒杆菌分泌的一种生物毒性蛋白质,其药理机制是与胆碱能神经末稍SNAP-25等蛋白产生作用,抑制乙酰胆碱释放,减少肌肉收缩和痉挛。目前,A型肉毒杆菌毒素获准用于治疗皱纹,其疗效平均持续4～6月,可以反复注射治疗。本文系统的回顾了A型肉毒杆菌毒的作用机制、临床试验、临床应用及不良反应。大量研究和病例分析已证明肉毒杆菌毒素注射术对于治疗面部各部位的皱纹是安全有效的。

Botulinum Toxin type A is the most poisonous substance known.The toxin is a zinc proteinase that cleaves 1 or more of the fusion proteins by which neuronal vesicles release acetylcholine into the neuromuscular junction.The treatment of glabellar lines is one of indications approved for botulinum toxin injection(BOTOX COSMETIC).The clinical studies demonstrated that the toxin can temporarily improve the appearance of moderate to severe glabellar lines associated with corrugator and/or procerus muscle activity.This article reviews the pathogenesis and clinical manifestations,injection skills,possible risks and adverse events of botulinum toxin.