摘要
为寻找治疗乙型肝炎肝纤维化的有效措施。方法;应用a1型基因工程干扰素(IFN-a1)和中药制剂治疗乙型肝炎肝纤维化患者40例,并观察治疗前后血清层粘蛋白、Ⅲ型前胶原、透明质酸、肝活检、B超、纤维胃镜等指标变化。结果:治疗3个月后,肝纤维化血清指标获得明显下降,与治疗前比较具有显著性差异(P<0.001);肝活检、B超、纤维胃镜证实肝纤维化获得改善;疗程结束6个月时,测定血清肝纤维化指标及白蛋白、球蛋白,IFN-a1效应型与无效应型比较也具有显著性差异(P<0.001)。结论:应用IFN-a1抑制乙型肝炎病毒复制、中药制剂抗肝纤维化具有较好疗效。
To find the effective method of curing hepatic fibrosis of hepatitis B. Methods: Using interferon a1and Chinese medical preparation to treat patients with hepatic fibrosis of hepatitis B and the comprehensive indexes,including levels of laminin, precollagen type Ⅲ and hyaluronic acid, liver puncture, ultrasonographic and fiber-gastroscopic examination were observed before and after treatment. Results:After 3 months of treatment, the fibroticindexes lowered obviously,in comparing with those before treatment, the difference was significant (P<0. 001 ).Liver biopsy, B-type ultrasonographic and fiber-gastroscopic examination proved that the hepatofibrosis was improved. The hepato-fibrotic indexes, blood albumin and globulin level were re-examined after 6 months, resultsshowed that the difference between the IFN-effective group and the IFN-ineffective group was significant, P<0.001. Conclusions:Beneficial effect might be obtained by using IFN-a1 to suppress the replication of hepatitis Bvirus and Chinese medical preparation to treat hepatic fibrosis.
出处
《中国中西医结合杂志》
CAS
CSCD
北大核心
1997年第8期453-455,共3页
Chinese Journal of Integrated Traditional and Western Medicine
基金
贵州省科委"科委"重点项目
贵州省科委"九五"攻关项目
关键词
乙型肝炎
肝纤维化
干扰素
中药制剂
肝活检
层粘蛋白
hepatitis B
hepatofibrosis
interferon
Chinese medical preparation
liver biopsy
laminin