移动条照射加用中药治疗原发性肝癌临床观察

Clinical Study of Combined Chinese Herbal Medicine with Move Stripe Field Radiation in Treating Primary Hepatocellular Carcinoma

观察全肝移动条照射加用中药血府逐瘀汤治疗原发性肝癌的效果。方法：采用双盲随机分组法对全肝移动条照射加用血府逐瘀汤治疗（中药组３０例）与照射加用安慰剂（对照组３０例）治疗的原发性肝癌患者进行临床前瞻性对照研究。结果：中药组患者１、３、５年生存率较对照组患者分别提高２０．０％、２３．４％和１６．６％，其放射性肝炎的发生率与对照组患者相比减低１６．６％，两组患者的远处转移率比较无统计学意义。结论：全肝移动条照射加用中药血府逐瘀汤对肝癌细胞的杀伤具有协同作用，可以提高肝癌细胞的放射敏感性，增加正常肝脏组织的放射耐受性，减低放射治疗的副作用。

To find a more effective treatment of primary hepatocellular carcinoma by using combined therapy ofChinese herbal medicine with radiotherapy. Methods: Prospective study was conducted with double-blind method onprognosis of patients treated with combined therapy of Xuefu Zhuyu decoction and move stripe field radiation on entire liver. A control group was established and treated with placebo and radiotherapy. Results: The 1-, 3- and 5year survival rates of the test group were higher than those of the control group by 20. 0 %, 23. 4 % and 16. 6 % respectively. The remote metastatic rate of the two groups were not different significantly. Conclusions: XuefuZhuyu decoction showed coordinative effect with radiotherapy on antitumor, it could enhance the radiosensitivity ofliver cancer cells, increase the radiation tolerance of normal hepatocytes and reduce the side effect of radiotherapy.