逐瘀通腑合剂抗内毒素所致肠源性感染的实验研究

Experimental Study on Effect of Zhuyu Tongfu Mixture on Anti-Enterogenous Infection Caused by Endotoxin

观察逐瘀通腑合剂抗内毒素所致肠源性感染的作用。方法：采用内毒素所致小鼠肠源性感染模型，测定小鼠内脏细菌移居阳性率、含菌量及ＳＯＤ活性。结果：治疗组小鼠细菌移居阳性率和各内脏含菌量显著低于内毒素组和安慰剂组（Ｐ＜０．０１）；治疗组小鼠各组织ＳＯＤ活性明显高于内毒素组和安慰剂组（Ｐ＜０．０５～０．０１）；病理学显示，逐瘀通腑合剂能明显减轻内毒素所致小肠粘膜损伤。结论：逐瘀通腑合剂对内毒素所致肠源性感染具有显著的治疗作用。

To evaluate the effect of Zhuyu Tongfu mixture(ZYTFM) in curing enterogenus infection. Methods: Experimental model of enterogenous infection in mice caused by endotoxin was used. The positive translocation trate(PTR)and mumber of viable bacteria in viscera and serum level of superoxide dismutase (SOD)were measured before and after ZYTFM treatment. ResultS: The PTR and number of viable bacteria in liver, spleen and mesocolon in the ZYTFM group were much lower than those in the model group and the placebo group(P＜0. 01 ). Whereas the SOD level of the ZYTFM group was significantly higher than that in the latter two groups(P＜0. 05～0. 01).Pathological examination displayed that ZYTFM could markedly alleviate the mucosal damage of small intestine.Conclusion: ZYTFM has an obvious curative effect on enterogenous infections induced by endotoxin.