绞股蓝总甙对高脂血症大鼠脂质水平的影响

The Effects of Gypenoside on Experimental Hyperlipidemia in Rats

观察了绞股蓝总甙(GYP)对实验性高脂血症大鼠脂质水平的影响。结果显示:GYP(每天150mg/kg)能显著降低高脂血症大鼠血清总胆固醇、甘油三酯水平,提高高密度脂蛋白浓度;使肝脏、主动脉壁胆固醇含量下降。实验还发现 GYP 能降低高脂血症大鼠血和肝脏过氧化脂质浓度,提高超氧化物歧化酶活性。提示:GYP 具有降脂保肝、防治动脉硬化形成的作用,这与 GYP 提高抗氧化酶活性、降低过氧化脂质浓度及其对肝细胞、动脉内皮细胞的损害有关。

The rats with hyperlipidemia were orally treated with the gypenoside(150mg/kg·d)for 12 weeks.The results showed that the blood levels of TC and TG in serum were significantly decreased,and the concentration of HDL-c yeas greatly increased.The contents of TC in the rat’s liver and aortic wall were also significantly decrease.It was also found that the concentration of LPO in serum and livers of the rats with hyperlipidemia was markedly reduced by gypenoside,however,the activity of SOD was ele- vated.These results suggested that gypenoside possessed strong effects on hyperlipidemia together with hepatic-damage and atherosclerosis.