川芎预防环孢素A急性肾中毒的实验研究

Preventive Effect of Chuangxiong on Acute Nephrotoxicity of Cyclosporine A in Rats

将 SD 雄性大鼠30只随机分为3组,Ⅰ组为假处理空白对照组;Ⅱ组为环孢素 A(Cyclosporing A,CsA)中毒组,给大鼠每天灌服 CsA50mg/kg,连续用药7天;Ⅲ组为川芎预防组,在同样灌服 CsA 的基础上预防性腹腔注射川芎。于用药前后分别检测大鼠的肾功能、尿酶等指标,最后进行肾脏光镜检查。结果证实,川芎对 CsA 急性肾中毒的发生具有预防作用。

This study was designed to prevent the acute nephrotoxicity of cycloporine A(CsA)with a Chinese herb,Chuangxiong (Ligusticum wallichii).Thirty male Sprague-Dawley rats were equally divided into three groups.Group Ⅰ was for control; group Ⅱ received CsA(50mg/kg)daily by gavage for 7 days;group Ⅲ received CsA with Chuangxiong intraperitoneally.Be- fore and on day 7 of treatment,rat body weight,renal function,urinary enzyme were measured.On day 7,kidneys were exam- ined under light microscope.The results indicated that CsA produced an acute impairment of renal function,and Chuangxiong could prevent the acute nephrotoxcity of CsA on function and morphology.