温肺化痰口服液的药理作用研究

Study on Pharmacological Action of Wenfei Huatan Oral Liquid(温肺化痰口服液)

温肺化痰口服液能增加大、小鼠痰液的排泌量,能抑制小鼠氨水及豚鼠由枸橼酸喷雾所致之咳嗽,减轻组胺和乙酰胆碱混合液喷雾所致之豚鼠哮喘,能延长其潜伏期。本品能显著对抗组胺引起的离体豚鼠气管螺旋条的收缩,能减轻二甲苯引起的小鼠耳廓肿胀,也能减轻小鼠棉球肉芽肿的重量,表明对急性炎症有消炎作用,同时也能抑制慢性炎症的结缔组织增生。

Wenfei Huatan oral liquid (WFHTOL) is a composite recipe of Chinese herbal medicine.It consists of eleven kinds of Chi- nese medicine,such as Ephedre sinica,Pinellia ternata,Prunus armeniaca,Perilla frutescense acuta,Magnolia biloba,Citrus aurantium,Asarum sieboldi.The pharmacological experiment showed that WFHTOL could:(1) Depress cough reflex in mice and guinea pigs caused by inhaling ammonia water and citrate,increase expectorant significantly in mice and rats.(2) Decrease the asthma of guinea pig to inhale the mixture liquid of histamine(His) and acetylcholine(Ach),prolong the incubation period.(3) Markedly suppress the contraction of isolated spiral strips of trachea,and relaxed the spasmodic contraction of the spiral stripe trachea caused by His in guinea pig.(4) Anti-inflammotory effect demonstrated by xylene induced ear swelling in mice,lowered the weight of cotton ball induced granulations in mice.(5) Alleviate wheezing for acute or chronic bronchitis,cough,asthma accumulation of phlegm and saliva.The toxicity of WFHTOL is very low,the tolerance was 240 g/kg(4.8 g/20 g) in mice (PO).