黔岭藿合剂对大鼠卵巢切除诱发实验性骨质疏松症的影响

Experimental Study of Epemedium Leptorrhizum Agent on Osteoporosis Induced by Ovariectomy

黔岭藿合刺是一个治疗骨质疏松症的复方。结果表明:大鼠去势后3个月可建立绝经后高转型骨质疏松症模型。治疗3个月后,中药组、尼尔雌醇组较模型组空腹尿钙/肌酐、羟脯氨酸/肌酐比值均明显降低(P<0.05,P<0.01);血清雌二醇/肌酐比值均明显降低(P<0.05,P<0.01);血清雌二醇升高;而中药组血清骨钙素(S-BGP)高于尼尔雌醇组、模型组(P<0.05);尼尔雌醇组血清碱性磷酸酶均低于中药组、模型组(P 均<0.05)。黔岭藿合剂能改善骨质疏松模型大鼠的骨丢失状态,起到保护骨骼作用。

Epeedium Leptorrhizum Agent （ELA） is a mixture of Chinese herbal medicine on osteoporosis.The results of the experi- ment showed that:three months after ovariectomy,the model of high turn-over osteoporosis occured in rats.Three months after ELA treatment,compared with the model group,the ratio of urine-Ca/Cr and urine-Hyp/Cr in both ELA and nilestriol groups obviously decreased （P<0.05,P<0.01）;the levels of serum-E2,BMC and BMD rose;the level of S-BGP in ELA group was higher than that in both nilestriol and model grouops （P<0.05）;the level of serum-AKP in nilestriol group was lower than that in both herb ELA and model groups （P<0.05）.The results indicated that ELA could improve osteoporosis.