摘要
观察了北豆根总碱对大鼠腹腔肥大细胞组胺释放的影响。结果表明,北豆根总碱能抑制化合物48/80诱导的大鼠腹腔肥大细胞脱颗粒释放组胺,其抑制作用与剂量呈量效关系。提示:北豆根总碱能稳定肥大细胞膜,阻止其脱颗粒释放各种活性介质,从而发挥拮抗Ⅰ型变态反应的作用。
The effect of total alkaloids of menispermum dauricum (TAMD) on the release of histamine from rat peritoneal mast cells induced by compound 48/80 was investigated.The results shiw that TAMD could inhibit the release of histamine from rat peri- toneal mast cells in dose-dependent manner,suggesting that TAMD could stabilize the membrane of mast cells and inhibit mast cells degranulstion,thus antagonize type-Ⅰ allergic reaction.
出处
《中国中西医结合杂志》
CAS
CSCD
北大核心
1997年第S1期184-185,298,共3页
Chinese Journal of Integrated Traditional and Western Medicine
关键词
北豆根总碱
大鼠腹腔肥大细胞
化合物48/80
total alkaloids of Menispermum dauricum
rat peritoneal mast cells
compound 48/80
