头孢地尼与头孢特仑酯随机对照治疗细菌性感染

A randomized comparative study of cefdinir and cefteram pivoxil in the treatment of bacterial infections

目的 :以头孢地尼和头孢特仑酯随机对照治疗急性轻中度呼吸道、泌尿道及皮肤软组织感染 ,评价头孢地尼的疗效及安全性。方法 :31例患者接受头孢地尼 10 0～ 2 0 0mg ,每日 3次 ;35例接受头孢特仑酯 10 0～ 2 0 0mg ,每日 3次 ,疗程 7～ 14d。结果 :试验组和对照组痊愈率和有效率分别为 74 .2 %、80 .0 % (P >0 .0 5 )与 96 .8%、97.1% (P >0 .0 5 )。两组的细菌阳性率、清除率分别为 87.1%、85 .7% (P >0 .0 5 )和 96 .3%、93.3% (P >0 .0 5 )。临床分离的 5 7株致病菌对头孢地尼、头孢特仑酯、头孢克肟、头孢克洛、阿莫西林和环丙沙星的敏感率分别为 87.7%、98.2 %、4 7.4 %、82 .5 %、4 3.9%和 6 3.2 % ;头孢地尼与头孢特仑酯、头孢克洛相比差异无显著性 (P >0 .0 5 ) ,但与头孢克肟、阿莫西林和环丙沙星相比差异有显著性 (P <0 .0 5 )。两组不良反应发生率分别为 4 .9%和 9.1% (P >0 .0 5 )。结论 :头孢地尼治疗轻、中度细菌感染安全、有效。

Objective: To evaluate the clinical efficacy and safety of cefdinir in the treatment of mild and moderate bacterial infections. Methods: 31 patients in study group were treated with cefdinir 100-200?mg po tid and 35 patients i n control group with cefteram pivoxil 100-200?mg po tid for 7 to 14 days. R esults: The cure rates and the effective rates of cefdinir and cefteram groups were 74.2%, 80.0% ( P >0. 05) and 96.8%, 97.2% ( P >0.05),respectively. The bacterial positive rates an d bacterial eradicat ion rates of the two groups were 87.1%, 85.7%( P >0.05) and 96.3%, 93.3% ( P >0.05), respectively. The susceptibility rates of 57 bacterial strains to cefdinir?cefteram p ivoxil?cefixime?cefaclor?amoxicillin and ciprofloxicin were 87.7%, 98.2%, 47. 4%, 82.5% , 43.9% and 63.2%, respectively. Adverse events were few and mild, being 4.9% and 9.1%,respectively in the two groups. No statistically significant difference was detected between the two groups. Conc lusions: Cefdinir is an effective and well tolerated antibacteri al agent for the treatment of mild and moderate bacterial infections.