培哚普利对高血压病患者血清一氧化氮及血管紧张素转化酶的影响

The effect of perindopril on nitric oxide and angiotensin converting enzyme in serum of patient with essential hypertension

目的 :探讨培哚普利对血管内皮的影响及对高血压病的疗效。方法 :采用硝酸还原酶法和化学比色法检测高血压病患者血清一氧化氮 ( Nitric oxide,NO)和血管紧张素转化酶 ( Angiotensinconverting enzyme,ACE)的水平 ,并观察培哚普利治疗前后血压的变化。结果 :1治疗前 ,高血压病组血清 NO浓度显著低于对照组 ( P<0 .0 1 ) ,而血清 ACE活性明显高于对照组 ( P<0 .0 5 ) ;血清NO浓度及 ACE浓度与高血压病分期呈负相关。 2治疗 2周后较治疗前血清 NO水平显著升高( P<0 .0 5 ) ,且分期越高 ,血清 NO浓度变化越显著 ;同时 ,高血压病患者血浆 ACE活性较治疗前明显降低 ( P<0 .0 5 ) ,但随分期的加重 ,血清 ACE水平治疗前后变化差值明显减小。 3靶器官受损组较未受损组血清 ACE活性明显降低 ,且治疗前后差值前者明显小于后者 ( P<0 .0 5 )。结论 :培哚普利有显著的降压疗效 ,并延缓高血压病动脉硬化的进展及减弱高血压病靶器官的受损程度。

Objective: To investigate the effects of perindopril on the vascular endothelium and on the cure of essential hypertension(EH). Methods: Determine level of nitric oxide (NO) and angiotensin converting enzyme (ACE) in serum and observe blood pressure in the patients with EH treated with perindopril. Results:① The concentration of NO in patient sera before treatment was obviously lower than that of the control group ( P <0.05) and the concentration of ACE in patient serum before treatment was higher than that of the control group ( P <0.05). There was inverse ralationship between both NO and ACE concentration and EH stage. ② The level of NO in serum after treatment with perindopril for two weeks was increased ( P <0.05), however, the level of ACE 2 week after being treated was lower than that before administration ( P <0.05). ③The level of ACE in serum of target organ injuried group was lower than that that of the normal group and the difference between pretreatment and posttreatment in injuried group was less than that in the group without injury. Conclusion: Perindopril may decrease significantly blood pressure, postpone the progression of atherosclerosis in EH and lighten the injury of target organ of EH.