小儿退热贴抗炎作用的实验研究

An Experimental Study of the Anti-inflammatory Effect of Xiaoertuiretie (Antipyretic Strapping for Children)

目的 :评价小儿退热贴的抗炎作用。方法 :参考相关文献制成小鼠耳廓炎性肿胀及醋酸致小鼠腹腔毛细血管通透性增高的模型 ,随机分为小儿退热贴大、中、小剂量组 ,0 .9%氯化钠溶液组和西药组各 10只 ,分别给予治疗。治疗后处死动物 ,测量致炎耳廓的肿胀度和腹腔冲洗液的吸光度 ,以评价小儿退热贴的抗炎作用。结果 :小儿退热贴对二甲苯所致小鼠耳廓炎症有明显的抑制作用 ,对醋酸所致小鼠腹腔毛细血管通透性增高有明显抑制作用。结论 :小儿退热贴有抗炎作用。

Objective:To appraise the anti inflammatory effect of Xiaoertuiretie . Method:With reference to relevant literature, two mouse models were set up, namely, inflammatory edema of the auricular concha caused by dimethylbenzene and increased permeability of abdominal capillaries resulted from the action of acetic acid. The mice were randomly divided into 5 groups, subjecting to large, medium and small dosages of Xiaoertuiretie strapping, 0.9% sodium chloride solution and prednisolone acetate (administered by stomach tubes) treatment, respectively. The animals were sacrificed after the treatment. The extent of inflammatory ear swelling and the absorbance of abdominal lavage fluid were determined so as to assess the anti inflammatory effect of Xiaoertuiretie . Results: Xiaoertuiretie was shown to exert a dramatic inhibitory effect on the inflammation of mouse's ear caused by dimethylbenzene and the increased permeability of capillaries in the abdominal cavity of the mouse caused by acetic acid. Conclusion: Xiaoertuiretie has a remarkable anti-inflammatory effect.