甲氧氯普胺联合苯海拉明预防化疗所致呕吐

Effect of Metoclopramide Combined with Diphenhydramine in the Control of Vomiting Caused by Chemotherapy

目的 :观察甲氧氯普胺联合苯海拉明的止吐效果。方法 :80例癌症化疗的患者 ,随机分为两组 ,即治疗组42例和对照组 3 8例。治疗组于化疗前 3 0min给予口服 2 5mg苯海拉明 ,于化疗开始后 2h静脉推注甲氧氯普胺 2 0mg ,以后每 4h推注 2 0mg ,至化疗结束 ;对照组采用 0 .9%氯化钠溶液 2 0mL加昂丹司琼 8mg于化疗前 3 0min静脉推注 ,隔日再静脉推注 8mg至化疗结束。比较两组疗效。结果 :治疗组呕吐的控制有效率为 86.4% ,对照组呕吐的控制有效率为86.2 % ,两组比较差异无显著性 ,P >0 .0 5。结论 :甲氧氯普胺联合苯海拉明的止吐效果与昂丹司琼相同。

Objective:To survey the antemetic effect of metoclopramide combined with diphenhydramine in patients subjected to chemotherapy. Method:80 cancer patients to be subjected to chemotherapy were randomly divided into two groups, the treatment group (42 cases) and the control group (38 cases). Patients of the treatment group were given each 25 mg of diphenhydramine PO 30 min before chemotherapy, 20mg of metoclopramide IV 2h after the beginning of the chemotherapy, followed by 20 mg of the same drug IV q.4h. until the termination of the chemotherapy. Patients of the control group received each 8 mg of ondansetron in 20 mL of 0.9% sodium chloride solution IV 30 min before chemotherapy, followed by 8 mg of the same drug IV every other day until the termination of the chemotherapy. The therapeutic effectiveness of the two groups was compared. Results:The rate of complete control of vomiting in the treatment group was 86.4%, while that in the control group, 86.2%. The difference was insignificant ( P >0.05). Conclusion:The antemetic effect of metoclopramide combined with diphenhydramine was found to be comparable with that of ondansetron in cancer patients subjected to chemotherapy.