神经纤维瘤病的MRI诊断

MRI diagnosis of neurofibromatosis

目的探讨神经纤维瘤病的MRI表现及特征。方法回顾性分析了13例神经纤维瘤病的MRI表现,其中神经纤维瘤病1型(NF-1)8例,神经纤维瘤病2型(NF-2)5例。分析病变的部位、大小、数目及MRI表现。结果病灶发生于桥小脑角区8例、三叉神经区3例、颞下窝2例、口咽及鼻咽部3例、颈部5例、腰椎管6例,颈静脉孔区及枕骨大孔区各2例。合并脑膜瘤4例、胶质瘤1例。11例神经纤维瘤病与颅神经或外周神经关系密切。在T1WI上为稍低或等信号,T2WI上为高信号,较小的肿瘤信号均匀,瘤体大时易出现坏死囊变,钆喷替酸葡甲胺增强后肿瘤实质部分明显强化。结论结合肿瘤的部位、数目、与神经的关系及临床资料,MRI能对神经纤维瘤病作出正确诊断。

Objective To investigate the MRI characteristics of neurofibromatosis.Methods MRI findings of 13 cases with neurofibromatosis were analyzed retrospectively. Among them ,8 cases were neurofibromatosis-1(NF-1),5 cases neurofibromatosis-2(NF-2). The location, size, number and signal intensity of neurofibromatosis were investigated. Result Neurofibromatosis was distributed extensively. Among the 13 cases with neurofibromatosis, 8 cases occurred in cerebellopontine angle,3 cases in the trace of trigeminal nerve,2 cases in zygomatic fossa, 3 cases in oropharynx and nasopharynx,5 cases in the neck, and 6 cases in vertebral canal. Four cases were accompanied with meningoma, 1 case with glioma. Eleven cases were correlated with nerves well. Most tumors were hypointense to isointense on T1WI images and mildly to strongly hyperintense on T2WI images, and tumor components were enhanced obviously with Gadolinium-DTPA injection except necrotic and cystic tissue .Conclusion To combine location, size, number, correlation with nerves and clinical findings of lesions, MRI can diagnose neurofibromatosis accurately.