原发性非小细胞肺癌中MTS2/p15的表达及临床意义

Expression of MTS2/p15 gene product and its clinical significance in primary non-small cell lung cancer

目的 探讨 p15基因在人非小细胞肺癌中的表达及其转移和预后之间的关系。 方法 应用免疫组化法对13 8例人非小细胞肺癌中 p15基因表达进行研究 ,同时以 2 3例正常肺组织作对照。 结果 肺癌 p15表达水平 (65 .66% )明显低于正常肺组织 (89.43 % ) (P <0 .0 5 )。p15表达水平降低的程度与肺癌的转移有密切关系 (P <0 .0 5 ) ,而与肺癌的原发肿瘤大小 (T) ,肿瘤部位 ,患者年龄及吸烟与否均无明显关系 (P >0 .0 5 )。p15高表达组 (>65 % )术后 5年生存率明显高于低表达组 (≤ 65 % ) (P <0 .0 5 )。Cox比例风险模型的多因素分析表明 p15 ,淋巴结转移状态 ,TNM分期是独立的判断预后的指标。结论 MTS2 /p15基因可能参与人体非小细胞肺癌的发生、发展和转移过程 ,它也是一个较有价值的预后判断指标。

ObjectiveTo explore the relationship between the expression level of MTS2/p15 gene and the metastasis and prognosis of human primary non-small cell lung cancer (NSCLC).MethodsWe studied the level of epxression of the p15 gene in 138 human NSCLC tissues using immunnohistochemistry,with 23 specimens of normal lung tissues as control.ResultsThe level of p15 gene expression (65.66%) in lung cancer tissues was significantly lower than that in normal lung tissue (89.43%) (P<0.05).The level of its decrease was closely related to metastasis of lung cancer,but not to the size,location,age and history of smoking (P>0.05). The 5-year survival rate of the patients with high expression of p15 (>65%) was significantly higher than those with low expression (≤65%).With Cox′s multivariate analysis,we found that MTS2/p15 epxression,lymph node metastasis and TNM stages had independent value in judging the prognosis of patients.ConclusionMTS2/p15 gene may be involved in the oncogenesis,development and metastasis of human non-small cell lung cancer,which is useful indicator in predicting the prognosis of NSCLC.