支气管动脉灌注化疗药物联合放疗治疗小细胞肺癌的临床分析

Clinical study on bronchial arterial infusion of chemotherapeutic drugs combined with radiotherapy in treatment of patients with small cell lung cancer

目的 观察支气管动脉灌注化疗药物联合放疗对治疗小细胞肺癌的近期疗效及全身副作用。方法 2 0 0 0年 5月～ 2 0 0 1年 5月 5 0例小细胞肺癌进入该研究。治疗组 2 5例 ,中央型 16例 ,周围型 9例 ,采用支气管动脉灌注丝裂霉素 +托马克 +顺铂 ,联合放疗。对照组 2 5例 ,中央型 14例 ,周围型 11例 ,采用丝裂霉素 +托马克 +顺铂单纯全身化疗。结果 治疗组有效率 92 %明显高于对照组的有效率 80 % ,但统计学上无显著性差异。治疗组中央型和周围型有效率分别为 94%和 89% ,全身副反应方面 ,如胃肠道反应、骨髓抑制 ,治疗组和对照组发生率分别为 16%、2 0 %和 72 %、64 % ,有显著差异性。结论 支气管动脉灌注化疗联合放疗治疗小细胞肺癌疗效较高 ,全身毒副反应少。

ObjectiveTo evaluate the short-time therapeutic efficacy and clinical toxic reaction of bronchial arterial infusion with MMC+VDS+DDP combined with radiotherapy in patients with small cell lung cancer(SCLC).MethodsFrom May 2000 to May 2001,50 patients with small cell lung cancer were enrolled in this study.Study group included 25 patients,of them ccntral type was 16 cases,peripheral type 9 cases.They were treated by bronchial arterial infusion of the chemical drugs with MMC+VDS+DDP combined with radiotherapy.Control group contained 25 patients,14 cases of central type,11 cases of peripheral type.They were treated by chemotherapy alone and with the same chemical drugs as those of the study group.ResultsThe response rates of the two groups were 92% and 80% respectively,suggesting that it was higher in study group than that in control group.But there was no statistical significant difference.The response rates of central type and peripheral type in study group were 94% and 89%,respectively.The occurrence of gastrointestinal irritation and myelosuppression of the two groups were 16%?20% and 72%?64%,respectively,showing statistical significant difference.ConclusionThe therapeutic efficacy of bronchial arterial infusion with chemical drugs combined with radiotherapy is more effective on small cell lung cancer with tolerant toxicity.