肺腺鳞癌的临床分析

Clinical analysis of adenos quamouscarcinoma of the lung

目的 分析和探讨肺腺鳞癌的病理学、生物学特性、临床表现和治疗特殊性及预后。方法 对本单位 18例肺腺鳞癌病人的临床资料进行回顾性研究 ,并结合文献进行讨论。结果 全部病人均给予手术切除 ,占同期肺切除手术的 6.10 % ,无围手术期死亡 ;术前无一例确诊 ,均经术后病理切片证实 ;病史平均 3 .88个月 ;X线检查周围型和中心型各有 10例和 8例。结论 肺腺鳞癌是临床上并不少见的肺恶性肿瘤 ,其生物学行为、治疗和预后有其特殊性 ,应和其它类型肺癌区别对待。临床表现和X线没有特点 ,痰查癌细胞和纤维支气管镜检出率低 ,术前确诊率低 ;分化差、恶性度高 ,易发生肺门淋巴结转移 ,预后差 ,五年生存率较其它非小细胞肺癌低 ;治疗以综合治疗为主 ,除积极手术治疗并清扫肿大淋巴结外 ,术后应给予放疗和化疗。

Objective Todiscusstheclinicalmanifestation ,thefeaturesofX ray ,thetreatmentandprognosischaracter isticsofadenosquamouscarcinomaofthelung .Methods Wereviewedtherecordsof 18consecutivepatientswithadenosqua mouscarcinomaofthelungtreatedsurgically .Results 18caseswereof 6.10 %ofthetotalpatientsadmittedwithlungcancer inthesameperiod .Therewerenopatientsdiagnosedbeforeoperation .Thetumorwasofcentraltypeandofperipheraltypein 8 patientsand 10patientsrespectively .Conclusion Adenosquamouscarcinomaofthelungisconsideredasapoorlydifferentiated tumor ,havingpoorerprognosis .Itiseasytoinvadetheadjacentorganandmetastasizeinearlystage .Theradiologicalfindingsof adenosquamouscarcinomaarenotspecificandthediagnosisisdifficultbeforeoperation .Thesurgicaltreatmentmustbecom binedwithchemotherapyandradiotherapy . [