膀胱癌组织中LM-R、nm23的表达及其与生物学行为关系的研究

LM-R,nm23 Expression and the Biologic Action in Bladder Carcinoma Tissues

目的 探讨膀胱癌不同组织中LM -R、nm 2 3表达的临床意义及其与生物学行为的关系。方法 应用免疫组化S -P法 ,检测 65例膀胱移行细胞癌及 19例非移行细胞癌组织中LM -R、nm 2 3的表达 ,并进行比较分析。结果 移行细胞癌组LM-R、nm 2 3阳性表达率分别为 3 2 .3 %(2 1 65 )和 60 .0 %(3 9 65 ) ,非移行细胞癌组LM -R、nm 2 3阳性表达率分别为 73 .7%(14 19)和 2 1.1%(4 19) ;2组LM -R、nm 2 3阳性表达率相比较有显著性差异 (P <0 .0 5 ) ,LM -R高表达、nm 2 3低表达者预后差。结论 非移行细胞癌浸润能力及转移能力均强于移行细胞癌 (LM -R高表达、nm 2 3低表达 ) ;LM -R、nm 2

Objective To investigate the clinical significance of LM R,nm23 expressions in different bladder carcinoma tissues.Methods The expression of LM R,nm23 were assayed by S P immunohistochemical method in 65 cases of bladder transitional cell cancer(BTCC) and in 19 cases of bladder notransitional cell cancer(BNTCC).Results The expression rate of LM R was 32.3%(21/65) in BTCC,lower than that(73.7%) in BNTCC,while the nm23 expression rate of 60.0%(39/65) in BTCC was higher than that of 21.1%(4/19) in BNTCC.Both groups had significant difference( P <0.05).Moreover,those patients with higher LM R and lower nm23 expressions had bad prognosis.Conclusion In bladder cancer,infiltrative and metastasis ability of BNTCC is superior to that of BTCC(LM R lower expression and nm23 higher expression).So LM R and nm23 expressions in bladder carcinoma tissue may act as the additional prognostic parameters.