期刊文献+

E-钙黏素和环氧化酶-2与结直肠癌的关系 被引量:3

E-cadherin(E-cd) and Cyclooxygenase-2(COX-2) Expression Correlate to Colorectal Cancer
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摘要 目的 探讨E -钙黏素及环氧化酶 -2在结直肠癌发生、发展中的意义。方法 应用免疫组化技术 (S -P法 )检测3 4例结直肠癌组织中E -钙黏素及环氧化酶 -2的表达。结果 E -钙黏素在结直肠癌中的表达强弱与癌组织的细胞分化程度、淋巴结转移和Dukes分期相关 (P <0 .0 5 ) ;而与发病年龄、性别及肿块部位无明显相关。 3 1例癌组织和 19例转移淋巴结中环氧化酶 -2表达明显升高 ,但与肿瘤的分化、分期、部位和患者的性别及年龄无明显关系。此外 ,E -钙黏素和环氧化酶 -2在癌组织中的表达与在正常肠黏膜中的表达相比较均有非常显著性差异 (P <0 .0 1)。结论 E -钙黏素和环氧化酶 -2的异常表达可能是结直肠癌发生、发展过程中的 1个重要环节 。 Objective To investigated the expression of E cd and COX 2 and evaluate their effects on the tumorigenesis and development of colorectal cancer.Methods The immunohistochemistry was used to determine the expression and location of E cd and COX 2 in the 34 colorectal cancer tissues.Results The E cd expression was correlated inversely to tumor differentiation,lymphonode metastasis and Dukes stage( P <0.05),whereas it was not correlated to the patients′ age,sex and the location of tumor.The level of COX 2 was increased in most of tumor tissues(31/34) and in all of the lymphonode metastases,but it was not correlated with the tumor differentiation,stage,location and patients′ age and sex.The expression of E cd and COX 2 was significantly different in tumor and nontumor tissues( P <0.01).Conclusion The abnormal expression of E cd and COX 2 plays a role in the carcinogenesis and development of colorectal cancer.
出处 《实用癌症杂志》 2002年第5期490-492,共3页 The Practical Journal of Cancer
关键词 E-钙黏素 环氧化酶-2 结直肠癌 免疫组织化学 淋巴结转移 E cadherin(E cd) Cyclooxygenase 2(COX 2) Colorectal cancer Immunohistochemistry Lymphonode metastasis
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参考文献3

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同被引文献17

  • 1姚宏,赵玛丽,王虹,平苏萍,张庆曰升,李新燕,孟德权,许彬,张爱莲,郝慧琴.β-连环素和上皮钙黏附素免疫组织化学检测在大肠癌中的研究[J].中国药物与临床,2004,4(9):672-676. 被引量:1
  • 2王爱娥,董书魁,王清娟,李雪丽.癌胚抗原在结直肠癌早期诊断和预后评估中的意义及其最新研究进展[J].中国临床康复,2004,8(32):7265-7267. 被引量:4
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  • 7Katoh M. Molecular cloning, gene structure, and expres sion analyses of NKD1 and NKD2[J]. Int J O ncol,2001, 19(5) :963 969.
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  • 9Zhang S, Wang Y, Dai SD, et al. Down-regulation of NKD1 increases the invasive potential of non-small-cell lung cancer and correlates with a poor prognosis [J]. BMC Cancer,2011,11(11) :186.
  • 10刘爱东,刘士生,许志萍,庞久玲.E-cadherin在胃癌中的表达及意义[J].广东医学,2007,28(11):1806-1807. 被引量:55

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