烫伤应激后大鼠肝组织α_1受体变化及意义

Significance of Alpha I-Adrenergic Receptor Changes Scald Stress in Rat Liver

用放射配基结合分析法测定正常和烫伤后6、12、48小时大鼠肝组织α_1受体,同时用放免和化学法分别测定了膜内第二信使cAMP和磷脂酶A_2活性,观察和分析了这些指标的动态变化和相对关系,认为烫伤后外周肝组织α_1受体功能活跃,应激反应对膜磷脂酶A_2的抑制可能对维持肝细胞膜的稳定和功能有一定意义。

The alpha I-adrenergic receptor in liver tissue of rats were determined by radio-ligand binding analytic method 6, 12, 48 hours after scald and normal group as well. At sametime, cAMP and phospholipase A2 also were determined by radioimmunoassay and chemiical methods. The results suggested that the function of alpha I-adrenergic receptor was activated after scald injuries, and the inhibition of phospholipase A2 by scald stress may have a role in maintaining the normal function of hepatocellular membrane.