前哨淋巴结显像研究

Detection of sentinel nodes by lymphoscintigraphy

前哨淋巴结系指原发肿瘤淋巴引流的第一级淋巴结,淋巴显像可准确定位前哨淋巴结及其数目,检出率达80%～100%。常用的前哨淋巴结显像剂有99Tcm-硫胶体、99Tcm-人血清白蛋白、99Tcm-右旋糖酐等。该法简便安全、实用性强,已先后应用于黑色素瘤、乳腺癌、妇科肿瘤等疾病的术前常规定位诊断,取得了很好的结果。

Sentinel lymph nodes(SLN)are regional lymph nodes first involved in metastatasis if lymphatic spread occurs.The SLN of solid tumor can be accurately identified by preoperative lymphoscintigraphy.Biopsy of the SLN is a highly precise,minimally invasive method of staging patients.The procedure may lead to a more justifiable approach to adjuvant therapy strategies with low complication.The SLN was identified in80%～100%patients by lymphoscintigraphy. 99 Tc m -sulfur colloid,99 Tc m -colloidal albumin and 99 Tc m -dextran has been the radiotracer for SLN mapping.Lymphoscintigraphy is a simple procedure that is well tolerated by patients.Until now,lymphoscintigraphy has been shown to effective for preop-erative lymphatic mapping and SLN localization in melanoma,breast cancer,and in other malignancies such as vulvar cancer.