肺心病患者血清碱性成纤维细胞生长因子水平的变化及其与肺动脉压的关系

The Change of Serum bFGF Level and Its Relationship to Pulmonary Arterial Pressure in Patients with Cor Pulmonale

目的 探讨碱性成纤维细胞生长因子 (b FGF)在低氧性肺动脉高压发病中的作用。方法 采用酶联免疫吸附法对具有低氧性肺动脉高压的肺心病患者 2 1例、无低氧性肺动脉高压的慢性阻塞性肺疾病 (COPD)患者 2 3例和 2 4例正常人血清 b FGF水平进行检测 ,以多普勒超声心动仪测定肺心病和 COPD患者的平均肺动脉压 (m PAP)。结果 肺心病组 m PAP水平 (33.33± 7.0 3m m Hg)明显高于 COPD组 (13.13± 2 .34mm Hg) ,P<0 .0 0 1;肺心病组血清 b FGF水平 (6 9.84± 16 .2 9pg/m l)明显高于 COPD组 (43.94± 7.5 7pg/ml)和正常对照组(44 .6 4± 6 .31pg/m l) ,P<0 .0 0 1;肺心病血清 b FGF水平与 m PAP之间呈明显正相关 ,r=0 .730 ,P<0 .0 0 1。结论慢性肺心病患者血清 b FGF水平明显升高 ,可能与其慢性低氧性肺动脉高压的形成有一定的关系。

Objective To assess the role of basic fibroblast growth factor (bFGF) in the development of hypoxic pulmonary hypertension. Methods The serum bFGF levels of 21 patients with cor pulmonale, 23 patients with chronic obstructive pulmonary disease (COPD) and 24 normal control subjects were measured by ELISA. The mean pulmonary arterial pressure in patients with cor pulmonale and in patients with COPD was measured by echocardiography. Results The level of mPAP in patients with cor pulmonale was significantly higher than that in patients with COPD, P <0.001; the concentration of bFGF in patients with cor pulmonale was significantly higher than that in patients with COPD and normal subjects, P <0.001. A positive correlation between the levels of bFGF and mPAP in patients with cor pulmonale was observed ( r =0.730, P <0.001). Conclusion The level of serum bFGF in patients with cor pulmonale is significantly increased; it may play an important role in the process of sustained pulmonary hypertension in patients with cor pulmonale.