癌基因C-erbB-2在宫颈癌组织中表达对放疗预后的影响

Oncogene C-erbB-2 expression in cervical carcinoma tissue to influence radiotherapeutic prognosis

目的 观察癌基因 C-erb B-2在宫颈癌组织中表达对放疗预后的影响。方法 宫颈癌组织标本取自我院 1980— 1981年放疗后满 10 a病例 99例 ,1996— 1998年放疗前确诊病例 2 9例。采用 LSAB免疫组织化学染色 ,细胞膜呈棕黄色反应为 C-erb B-2阳性。 60钴外照射总剂量 45 0 0～ 5 0 0 0 c Gy/B点 ,腔内治疗1 3 7铯 70 0 0～80 0 0 c Gy/A点或 1 92铱 42～ 5 0 Gy/A点。结果 在 5 1例放疗后满 10 a生存病例中 ,C-erb B-2阳性为 47% ,而死亡 48例中阳性表达 72 % ,P<0 .0 5。 2 9例放疗结束 :11例 C-erb B-2阳性 ,完全缓解 (CR)、部分缓解 (PR)各为72 .7%和 2 7.3 % ,18例阴性表达 ,CR、PR各为 72 .8%和 2 7.2 %。结论 放疗后满 10 a生存病例 C-erb B-2阳性表达明显低于死亡病例 (P<0 .0 1) ,差异有显著意义。C-erb

Objective To observe the expression of oncogene C erbB 2 in cervical cancer tissue influencing the radiotherapeutic prognosis.Methods Samples of 99 cases′ cervical cancer tissue were got from the cases in our hospital who have survived more than ten years after radiotherapy since 1980 to 1981.Before radiotherapy 29 cases were confirmed by pathology in 1996-1998,stained by LSAB immunohistochemistry.The cell membrane showing brown yellowwasC erbB 2positive.External irradiation used cobalt 60.Totaldose 4 500～5 000 cGy/point B.Intracavitary afterloading brachytherapy by cesium 137 7 000～8 000 cGy/point A or iridium 192 42～50 Gy/point A.Results In 51 cases of post radiotherapy for more than ten years C erbB 2 positive was 47%,but cases of the dead was 72% ( P<0 05 ).Of the29cases of complete radiotherapy 11 cases were C erbB 2 positive;CR,PR were 72.7% and 27.3% respectively.But in the 18 cases C erbB 2 negative,CR,PR were 72.8% and 27.2%.Conclusion Survival cases of more than ten years after radiotherapy have a lower positive than the dead cases (P<0 01).Whether the C erbB 2 expression is positive or negative,no near term effect can be given by the radiotherapy to cervical cancer.