标本兼治对支气管哮喘缓解期患者免疫功能的影响

Effect of "Treating Both the Principal and the Secondary Aspects of a Disease"on the Immune Function of the Patients in Remission Stage of Bronchial Asthma

目的 :探讨标本兼治对支气管哮喘缓解期免疫功能的疗效及机制。方法 :选 82例支气管哮喘缓解期患者 ,随机分为两组 ,治疗组 5 0例 ,对照组 32例 ,治疗组口服宣肺定喘丸和慢阻固本丸或哮喘固本丸 ,对照组口服左旋咪唑及肌注丙种球蛋白。 2组均 3个月为 1疗程 ,疗程前后分别测定免疫球蛋白 Ig G、Ig A、Ig M,并观察 3年内哮喘的发作次数。结果 :治疗组显效32例 ,有效 17例 ,无效 1例 ,总有效率为 98.0 % ;对照组显效 13例 ,有效 7例 ,无效 12例 ,总有效率为 6 2 .5 %。两组比较有显著性差异 (P<0 .0 1)。治疗组治疗后与本组治疗前及对照组治疗后比较免疫球蛋白有显著提高 (P<0 .0 5、0 .0 1)。结论

Objective:To observe the therapeutic effect and the mechanism of 'treating both the principal and the secondary aspects'on the immune function of the patients in remission stage of bronchial asthma.Methods:82 cases of bronchial asthma in remission stage were divided into two groups randomly.50 cases were treated with oral Xuanfeidingchuan pills(宣肺定喘丸) and Manzuguben pills(慢阻固本丸) or Xiaochuanguben pills(哮喘固本丸).32 cases treated with oral levamisole and gamma globulin injuction were set up as the control group.Both the two groups had been treated for 3 months.The blood IgG?IgA?IgM were detected before and after treatment.The frequency of asthma were observed within 3 years.Results:In the treatment group,32 cases had significant effect,17 cases effective and 1 case had no effect.The total effective rate was 98 0%;In the control group,13 cases had significant effect,7 cases effective and 12 cases had no effect.The total effective rate was 62.5%.There were significant differences between the two gruops(P<0 01).The blood immune globulins were increased after treatment and higher than that of the control group significantly(P<0 05,P<0 01).Conclusion:The immune function of the patients in remission stage of bronchial asthma and the therapeutic effects could be improved by treating both the principal and the secondary aspects.