葛根素注射液治疗冠心病心绞痛80例临床观察

Observation on Angina due to Coronary Cardiopathy Treated with Puerarin Injection,a Report of 80 Cases

采用葛根素注射液及口服硝酸酯类药治疗冠心病心绞痛 80例 ,与单纯口服硝酸酯类药治疗 4 0例作对照。结果 :两组临床症状疗效比较 ,治疗组显效 4 0例 ,有效 32例 ,无效 8例 ,总有效率为 90 .0 % (95 % CI=83.4 %～ 96 .6 % ) ;对照组显效15例 ,有效 13例 ,无效 12例 ,总有效率为 70 .0 % (95 % CI=5 5 .8%～ 84 .2 % ) ;两组综合疗效比较 ,有明显差异 (u=2 .1985 ,P= 0 .0 2 82 ) ;治疗组发生无效患者的危险性明显降低 (OR=0 .2 6 ,95 % CI=0 .10～ 0 .70 ) ;治疗组每治疗 5人 ,可较对照组减少1例无效患者 (NNT=5 ,95 % CI=2 .93～ 17.0 9)。两组心电图疗效比较 ,治疗组优于对照组 (OR=0 .4 4 ,95 % CI=0 .2 0～0 .96 ) ,但综合疗效未达明显差异 (u=1.80 5 0 ,P=0 .0 75 8)

cases of angina due to coronary cardiopathy were treated with puerarin injection and oral nitroglycerin,40 cases only treated with oral nitroglycerin were set up as the control group.Result:In the treatment group,40 cases had significant effect,32 cases effective and 8 cases had no effect.The total effective rate was 90.0%(95%CI=83.4%-96.6%).In the control group,15 cases had significant effect,13 cases effective and 12 cases had no effect.The total effective rate was 70.0%(95%CI=55.8%-84.2%).There were significant differences between the two groups(u=2.1985,P=0.0282);The incidence of inefficacy in the treatment group was lower than the control group significantly (OR=0.26,95%CI=0.10-0.70);Compared with the control group,1 cases of inefficacy could be vanished by treating 5 cases in the treatment group(NNT=5,95%CI=2.93-17.09).The treatment group was prior to the control group in electrocardiogram(OR=0.44,95%CI=0.20-0.96).But there was no significant differences between the two groups in the general therapeutic effect(u=1 8050,P=0 0758).