肺部恶性肿瘤患者血清总MMP-9检测及其临床意义

Detection of serum total MMP-9 and its clinical significance for lung neoplasms

目的 探讨检测血清总MMP 9在肺部恶性肿瘤中的临床应用价值。方法 采用抗人总MMP 9的单克隆抗体和夹心ELISA法检测 6 3例肺癌患者血清总MMP 9。结果 肺部恶性肿瘤患者血清总MMP 9为 ( 92 .2± 74.39) μg/L ,显著高于健康对照组 ( 9.5± 6 .74) μg/L(P <0 .0 5 )。伴淋巴结转移组患者血清总MMP 9水平显著高于无淋巴结转移组 (P <0 .0 5 )。进展组 (PD)和死亡组血清总MMP 9水平显著高于完全缓解组 (CR)和部分缓解组 (PR) (P <0 .0 5 )。肺部恶性肿瘤患者血清总MMP 9水平与血清CA2 42水平存在显著的负相关 (P =0 .0 2 1)。结论 血清MMP

Objective To investigate the clinical value of serum total MMP-9 detection in lung malignancies. Methods Serum total MMP-9 levels were detected in 63 patients with lung malignancies by sandwich ELISA with monoclonal antibody against human total MMP-9. Results Serum total MMP-9 was (92.2± 74.39) μg/L in lung malignancy group, which was significantly higher than that of healthy control [(9.5± 6.74) μg/L](P<0.05). In lung cancer group, there were significant differences in serum total MMP-9 level between patients with and without lymph node metastasis, and between progressive disease+death group and complete response+partial response group. Significantly negative correlation was observed between serum CA242 and serum total MMP-9 levels (P=0.021). Conclusion Detection of serum total MMP-9 may be helpful to predict metastasis and treatment response of lung cancer.