晚期肺癌患者心功能状况及影响因素分析

Heart function in patients with advanced lung cancer

目的 探讨晚期肺癌患者的心功能状态及影响心功能的因素。方法 前瞻性对 6 0例晚期肺癌患者进行超声心动图检查 ,并将有心衰症状和体征者分为治疗组和对照组 ,对比分析疗效和生存时间。结果 晚期肺癌患者心功能不全的发生率为 6 0 % ,2 4例大量恶性胸腔积液和心包积液的患者心功能均为Ⅱ～Ⅳ级。既往有冠心病、高血压和糖尿病史者发生心衰的时间显著早于无冠心病、高血压和糖尿病病史者。抗心衰治疗可明显改善症状及延长生存时间。化疗对心功能不全的发生无明显影响。结论 伴有大量恶性胸腔积液和心包积液的晚期肺癌患者均存在心功能不全 。

Objective To evaluate the incidence and effective factors of cardiac dysfunction in patients with advanced lung cancer. Methods Echocardiography were carried out in 60 patients with advanced lung cancer before treatment. According to heart function, patients were divided into treatment group and control group. Results The incidence of cardiac dysfunction in patients with advanced lung cancer was 60%. All patients with malignant pleural effusion and pericardial effusion had cardiac dysfunction. Cardiac dysfunction occurred much earlier when patients had previous history of coronary artery diseases, hypertension or diabetes. Treatment against cardiac dysfunction may improve symptoms and prolong survival time. The cardiac dysfunction in the patients with advanced lung cancer is not concerned in chemotherapy. Conclusion The incidence of cardiac dysfunction is closely related to patients' general condition, especially massive malignant pleural effusion and pericardial effusion. Treatment against cardiac dysfunction can significantly improve the clinical symptoms, life quality and survival time.