急性中度低压缺氧对飞行员血浆血管紧张素Ⅱ及肾上腺髓质素含量的影响

Effects of Acute Moderate Hypoxia on Plasma Angiotensin Ⅱ and Adrenomedullin in Pilots.

目的探讨急性中度低压缺氧对飞行员血浆血管紧张素Ⅱ (AⅡ )及肾上腺髓质素 (ADM)含量的影响。方法用放免法测定了 1 6名健康男性歼击机飞行员缺氧前 ( 6∶0 0 )、急性中度低压缺氧即刻 ( 1 0∶0 0 )及到达地面 6h后 ( 1 6∶0 0 )的血浆AⅡ及ADM的含量 ,并以 1 6名健康男性地面人员相应时间的测定作对照。结果 1 )缺氧前飞行员的血浆AⅡ及ADM含量与对照组比较差异无显著意义 (P >0 .0 5 )。2 )急性中度低压缺氧即刻 ,飞行员的血浆AⅡ及ADM含量较缺氧前明显增加 (P <0 .0 5 ) ,缺氧结束后 6h恢复到缺氧前水平。结论急性中度低压缺氧可导致飞行员血浆血管紧张素Ⅱ (AⅡ )及肾上腺髓质素 (ADM )的含量增加 。

Objective To study the effect of acute moderate hypoxia on plasma angiotensin Ⅱ(AⅡ) and adreomedullin(ADM) content in pilots.Method The concentration of plasma AⅡ and ADM was measured by radioimmunoassay in 16 healthy male pilots in the early morning(6∶00), following acute moderate hypoxic exposure(10∶00) and 6 h after returned to the ground(16∶00).Sixteen healthy male ground crews were set as control group,and their plasma AⅡ and ADM content was assayed at corresponding time.Result 1) Plasma AⅡand ADM content of pilot group and that of the control group was not different(P>0.05). 2)Plasma AⅡ and ADM content immediately after acute moderate hypoxic exposure in the pilot group was significantly higher than that of before hypoxia(P<0.05), and it returned to normal level 6 h after hypoxia. Conclusion Acute moderate hypoxia can induce temporarily increase of plasma AⅡand ADM in pilots.