肺癌中耐药相关因子的表达与吸烟的关系

Relationship between Expression of Drug Resistance Related Factors and Smoking Habit in Patients with Lung Cancer

目的 :研究肺癌患者中耐药相关因子表达情况与吸烟习惯的相关性。方法 :运用免疫组织化学方法对71例放化疗前肺癌外科手术标本进行3种耐药相关因子 (Pgp、GSTπ和MT)表达水平检测。结果 :单独表达时 ,各耐药因子表达均与吸烟相关 (P<0 05)。同时观察3者的总体表达时 ,有耐药因子表达 (至少有1种 )和多个耐药因子共同表达 (2种与2种以上 )亦与吸烟相关 (P=0 021 ,P=0 006)。结论 :吸烟导致肺癌中耐药因子表达增加 ,在治疗有吸烟史的肺癌患者时更应重视耐药问题 ,对其进行耐药相关检测 ,有助于选择合理治疗方案 ,提高疗效。

Objective:To study the relationship between the expression of drug resistance related factors and the smoking habit in patients with lung cancer Methods:The expression of three drug resistance related factors(Pgp,GSTπ and MT)in 71 untreated lung cancer specimens were studied by immunohistochemistry Results:There was a correlation between the expression of Pgp,GSTπ or MT and the somoking habit(P<0 05) A close correlation also exsited between the expression of one factor at least or multi factor(two or more)and the somoking habit(P=0 021 and P=0 006 respectively) Conclusion:The drug resistance is closely related to the smoking habit In order to cure a patient more effectively,it is important that some inspections about drug resistance should be taken in patients with lung cancer,especially those with smoking habit