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人体生理、物理因素对血管结构和功能的影响 被引量:1

Relationship between Physical, Physiological Factors and Arterial Structure and Function
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摘要 大动脉血管功能测定越来越多的被用作预测心血管疾病的替代指标,然而非常重要的是需要确定非病理因素是否可能影响到这些测量参数.对年龄、身高、体重指数、心率和血压等等生理因素与脉搏波速度(PWV)、系统动脉顺应性(SAC)、中心动脉压增加指数(A1)和颈动脉壁内中膜厚度(IMT)之间的相关性和影响进行评估.共选择285个正常志愿者,其中男性98例,女性187例,年龄50~82岁.结果经年龄校正后,脉搏波速度、系统动脉顺应性、颈动脉壁内中膜厚度和中心动脉压增加指数有显著的性别差异.系统动脉顺应性、中心动脉压增加指数与高度相关,而且此相关在性别上有明显差异.经年龄和性别校正后身体体重指数与SAC正相关,与AI负相关.经年龄、性别和身高校正后,脉搏波速度、中心动脉压增加指数与心率、中心脉压差呈显著地直线相关.这些结果可能意味着与心血管功能障碍的相关性:对矮身材的人来说,大动脉顺应性降低和中心压力附加值的增大是增加其心血管危险因素的潜在的生理因素;对于老年人来说,缓慢心率可能导致潜在的反效果即中心静脉压的增加.
出处 《南京大学学报(自然科学版)》 CAS CSCD 北大核心 2002年第5期636-643,共8页 Journal of Nanjing University(Natural Science)
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  • 1Blacher J, Guerin A P, Pannier B, et al Impact of aortic stiffness on survival in end-stage renal disease.Circulation, 1999, 99(18): 2 434-2 439.
  • 2Guerin A P, Blacher J, Pannier B, et al. Impact of aortic stiffness attenuation on survival of patients in end-stage renal failure. Circulation, 2001, 103(7): 987-992.
  • 3Cameron J D, Jennings G L, Dart A M. Systemic arterial compliance is decreased in newly-diagnosed patients with coronary heart disease: implications for prediction of risk. J Cardiovascul Risk, 1996, 3(6) :495-500.
  • 4O' Rourke M. Arterial stiffness, systolic blood pressure, and logical treatment of arterial hypertension.Hypertension, 1990, 15(4): 339-347.
  • 5Adams M R, Nakagomi A, Keech A, etal. Carotid intima-media thickness is only weakly correlated with the extent and severity of coronary artery disease. Circulation, 1995, 92(8): 2 127-2 134.
  • 6Salonen J T, Salonen R. Ultrasonographically assessed carotid morphology and the risk of coronary heart disease. Arterioscler Thromb, 1991, 11(5): 1 245-1 249.
  • 7Howard G, Sharrett A R, Heiss G, etal. Carotid artery intimal-medial thickness distribution in general populations as evaluated by B-mode ultrasound. Stroke, 1993, 24(9): 1 297-1 304.
  • 8Blankenhom D H, Seizer R H, Crawford D W, et al. Beneficial effects of colestipol-niadn the rapy on the common carotid artery. Two- and four-year reduction of intima-media thickness measured by ultrasound .Circulation, 1993, 88(1): 20-28.
  • 9Furberg C D, Adams H P, Jr Applegate W B, et al. Effect of lovastatin on early carotid atherosclerosis and cardiovascular events. Asymptomatic Carotid Artery Progression Study (ACAPS) Research Group.Circulation, 1994, 90(4) : 1 679-1 687.
  • 10Mercuri M, Bond M G, Sirtori C R, et al. Pravastatin reduces carotid intima-media thickness progression in an asymptomatic hypercholesterolemic mediterranean population: the Carotid Atherosclerosis Italian Ultrasound Study. Am J Med, 1996, 101(6): 627-634.

同被引文献5

  • 1Kobayashi K,Akishita M,Yu W,et al.Interrelationship between non-invasive measurements of atherosclerosis:flow-mediated dilation of brachial artery,carotid intima-media thickness and pulse wave velocity[J].Atherosclerosis,2004,173(1):13-18.
  • 2McDonald DA.Blood flow in arteries:theorical,experimental and clinical principles[M].4 th ed.London:Arnold,1998:77-142,216-269,283-359,398-437.
  • 3Zieman SJ,Melenovsky V,Kass DA.Mechanisms,pathophysiology,and therapy of arterial stiffness[J].Arterioscler Thromb Vasc Biol,2005,25(5):932-943.
  • 4LaurentS,Boutouyrie P,Asmar R,et al.Aortic stiffness is an independent predictor of all cause and cardiovascular mortality in hypertensive patient[J].Hypertension,2001,37(7):1236-1241.
  • 5Avolio AP,Deng FQ,Li WQ,et al.Effects of aging on arterial distensibility in populations with high and low prevalence of hypertension:comparison between urban and rural communities in China[J].Circulation,1985,71(2):202-210.

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