磁共振波谱成像在脑梗塞中的应用

The Clinical Study of^1 HMR Spectroscopy Imaging on Cerebral Infarction

通过采用SPSS10.0统计分析软件比较1D与2D1HMRS在显示脑中主要代谢物的差别及取相对浓度分析脑梗塞病灶内代谢物变化,为进一步选择优化序列及1HMRSI用于临床研究奠定基础.共35例分病例组和健康自愿者.健康自愿者正常基底节共采集1DMRS19个,2DMRSI76个.每例1HMRSI采集NAA、Cr、Cho、Lac4个主要代谢物波谱图.患者共采集2DMRSI64个.结果发现1D与2DMRSI中NAA、Cr、Cho、GLx、Lac、INS的半高宽之间有显著差异(P<0.05).在脑梗死病人中NAA明显降低而Lac升高(P<0.05).在脑梗塞病灶内100%发现Lac.发现在脑梗死1HMRS的研究中1D、2D均适合于显示各主要代谢物(NAA和Lac),2DMRSI可直观显示复杂的代谢物空间分布,1DMRS则采集时间短.在脑梗死灶内NAA明显降低而Lac升高是其主要变化特点.乳酸是脑缺血或脑梗塞早期敏感的标记物.

The different performances between 1D MRS and 2D MRSI in brain were achieved by SPSS 10.0 in order to optimize clinical sequences and application. 1H MRS were performed in 35 volunteers and patients. 19 1D MRS and 76 2D MRS in normal and 64 2D MRSI in infarction were acquired. The four main metabolites of 1H MRSI such as NAA?Cr?Cho?Lac were acquired.The effect between 1D MRSI and 2D MRSI to SNR?width at 50% and ratios of metabolites were investigated. There are prominent difference between the width at 50% of 1D and 2D, and the significances are less than 0.05. NAA is decreasing and Lac elevates obviously(P<0.05). 100% Lac elevation was detected in infarctions. 2D MRSI is a better sequence in showing changes of metabolites directly than 1D MRS. Then 1D MRS has a shorter scan time. The changing of NAA and Lac are characteristics in infarction. The elevation of Lac can be used as an identification of the early infartion.