血栓分子标志物的测定在2型糖尿病中的临床意义

Measurements of Thrombus Molecular Markers in Patients with Type 2 Diabetes Mellitus and its Clinical Significance

目的:对2型糖尿病(DM)患者血浆中血栓分子标志物进行检测,并探讨其临床意义。方法:均采用ELISA法测定DM病人及正常对照组血浆vWF、6-keto-PGFlα、tPA、D二聚体、P选择素水平。结果:DM病人vWF、D二聚体、P选择素水平较正常对照组高,而6-keto-PGFlα、tPA较正常对照组低,P值均≤0.01,有非常显著意义。结论:血栓分子标志物的检测对DM病人高凝状态的诊断具有很高的临床指导意义。

Objective: To measur the plasma level of thrombus molecular markers in patients with diabetes mellitus(DM) and to study its clinical significance. Methods: ELISA method was used to detect the plasma levels of von willabrand factor (vWF), 6-K-PGFlα, tPA, D Dimer and P selectin. Results: The plasma levels of vWF, D Dimer and P selectin in DM group were higher than those of the group and the levels of 6-K-PGF1α and tPA in DM group were lower than those of thd control group (P<0.01). It was significant difference between the two groups. Conclusion: The alteration of thrombus molecular markers would reveal a higher sensitivity for diagnosis of high coagultion state in DM patients.