血友病甲患者血浆中修饰型组织因子途径抑制物的研究

The Study on Trunpucated TFPI Level in Plasma of Hemophilia A

目的:探测血友病甲患者血浆修饰型组织因子途径抑制物(TFPI)水平的变化及其与活化部份凝血酶时间(APTT)时间的相关性。方法:以ELISA法测定修饰型TFPI含量,以凝血一期法在半自动凝血仪上测定APTT与FⅧ:C。结果:28例血友病患者血浆修饰型TFPI含量与正常组相比差异无显著性,与APTT呈正相关,与FⅧ:C不相关。结论:血友病甲患者修饰型TFPI含量与正常无差异,完全可能通过低调TFPI水平而达到止血冶疗的目的。

Objective: To explore and dectect the changes of the trunqucated tissue factor pathway in-hibitor(TFPI) level in plasma of hemophilia A and it's correlation between the activated partial thrombo-plastin time(APTT) and FⅧ:C. Methods: The volumn of the trunpucated TFPI is measured by means of ELISA method, the APTT and FⅧI:C is detected by the first cloting stage method. Results: There is no significant difference of the plasma TFPI volumn between 28 case hemophitia A and normal control group. The plasma TFPI volumn is positive correlation with the APTT. But no correlation with the FⅧ:C. Conclusion: The trunpucated TFPI volumn in plasma of hemophihia A is no significant differents to the normal, it is possible to low regulate the TFPI level so to regain the hemostasis theraputic purpose.