谷氨酸单钠对大鼠胃肠粘膜5-羟色胺表达的影响

THE EFFECT OF MSG ON THE EXPRESSION OF 5-HT IN GASTROENTERIC MUCOSA OF RAT

目的 探讨谷氨酸单钠对大鼠胃肠粘膜五羟色胺 (5 HT)表达的影响。 方法 采用免疫组织化学技术检测胃肠粘膜 5 羟色胺的表达并用图象分析系统进行定量。 结果 谷氨酸单钠可使胃肠粘膜 5 羟色胺表达增强 ,以 12 0d(成年期 )最为明显 ,5 2d(青春期 )次之 ,各组与对照组比具有显著性差异P <0 0 1。 结论 谷氨酸单钠可使胃肠粘膜 5 羟色胺表达增强 ,这可能是MSG导致神经内分泌紊乱的机制之一。

Objective To explore the effect of monosodium glutamate (MSG) on the expression of 5\|HT in gastroenteric mucosa of rat. Methods Immunohistochemical technique was used to detect the expression of 5\|HT. The immuno\|activity and the density of positive cells were measured by image analysis. Results The immuno\|activity and the density of 5\|HT positive cells(EC cell) in the experimental group are higher than that in control group. The effect by 120d is the most significant, followed by that of 52d. Statistical analysis showed a significant difference ( P< 0\^01).Conclusion MSG could increase the expression of 5\|HT in gastroenteric mucosa. This may be one of the mechanisms of neuroendocrine disorder induced by MSG.