^(99m)Tc-平阳霉素肺显像诊断原发性肺癌

^(99m)Tc-Pingyangmycin imaging in the diagnosis of primary lung cancer

目的 探讨99mTc 平阳霉素 (PYM)肺显像诊断原发性肺癌的临床价值。方法 对 5 6例原发性肺肿瘤患者行PYM肺显像。结果 肺癌与肺良性病变对 99m Tc PYM的摄取差异有显著性 ,以晚期摄取比值作为诊断肺恶性病变的阈值 ,其诊断的准确性、灵敏度及特异性分别为 82 .1%、82 .7%和 80 .0 %。以储留指数为阈值 ,则分别为 94 .6 %、93.0 %和 10 0 .0 %。肺癌不同组织学类型之间摄取差异无显著性。结论 99mTc

Objective To evaluate the clinical value of 99m Tc Pingyangmycin (PYM) imaging for the diagnosis of primary lung cancer. Methods Radionuclide 99m Tc Pingyangmycin (PYM) imaging was performed in 56 patients with pulmonary lesions. Results The uptake ratio and retention index (RI) were different in malignant and benign lesions. With the delayed ratio regarded as the threshold for lung cancer, the overall accuracy, sensitivity and specificity of 99m Tc PYM in the diagnosis of lung cancer were 82.1%, 82.7% and 80%, respectively. If RI was regarded as the threshold, the overall accuracy, sensitivity and specificity were 94.6%, 93% and 100%, respectively. There was no significant difference among different histological types of the lung carcinoma. Conclusion 99m Tc PYM, as a good imaging agent, is useful in differentiating malignant lung lesions from benign ones.