淫羊藿黄酮磷脂复合物大鼠体内药动学

Study on pharmacokinetic of herba epimedii total flavonoids and their phytosomes in rats

目的 :研究淫羊藿黄酮及其磷脂复合物 (EFL)中淫羊藿苷在SD大鼠体内药动学。方法 :以HPLC测定法测定大鼠血中淫羊藿苷的含量 ,以同组大鼠 (8只 ,♂♀各半 )交叉灌服淫羊藿黄酮及其磷脂复合物 ,药 时曲线数据经 3P87药动学计算程序处理。结果 :分别以淫羊藿黄酮及其磷脂复合物给SD大鼠灌胃 (剂量为淫羊藿苷 10 0mg·kg-l) ,淫羊藿苷的药 时过程符合一级动力学模型 ,淫羊藿黄酮中淫羊藿苷的AUC、Cmax、Tmax分别为 (6 2 .5± 4.7)mg·h·L-1,(5 .3± 1.6 )mg·L-1,(2 .9±0 .9)h ,而EFL中的为 (15 6 .1± 2 7.2 )mg·h·L-1,(17.5± 3.5 )mg·L-1,(2 .1± 0 .6 )h ,统计结果表明AUC、Cmax之间差异有显著性。结论

OBJECTIVE To study the phamarcokinetic of icariin flavonoids and its phytosomes in rats.METHODS Using HPLC to determine the icariin concentration in blood. Using the same group of rats to carry on the cross-experiments and using 3P87 phamarcokinetic program software to calculate data. RESULTS The concentration-time profiles of icariin after ig administration of total flavonoids and their phytosomes (equivalent to 100 mg·kg -1 of icariin) were shown to fit one-compartment open model with first-order absorption. Their AUC, C max,T max were ( 62.5± 4.7) mg·h·L -1?( 5.3± 1.6) mg·L -1?( 2.9± 0.9) h and ( 156.1± 27.2) mg·h·L -1?( 17.5± 3.5) mg·L -1?( 2.1± 0.6) h respectively. Difference in AUC, C max between them is significant.CONCLUSIONS Phospholipid can effectively enhance icariin absorption in rats.