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MMPs与结膜

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摘要 自1962年,Gross和Lapiere从蝌蚪的皮肤中首次发现基质金属蛋白酶(MMPs)的第一个成员-胶原酶以来,一系列的MMP家族成员已被陆续发现,迄今为止至少有19种MMP被发现.MMPs是一类锌离子依赖的蛋白水解酶,参与细胞外基质的降解.它们在有机体生长发育中的细胞外基质(ECM)更新与重塑以及疾病中的病理损害起着极为重要的作用.所有基质金属蛋白酶都受到天然抑制剂金属蛋白酶组织抑制剂(TIMPs)所抑制.两者的调节平衡在创伤修复、组织重建、新生血管和瘢痕形成以及肿瘤转移等疾病中起着重要的作用,它们也参与了眼科疾病的病理过程,现将MMPs与结膜的关系作一简要综述.
出处 《江西医药》 CAS 2002年第4期310-313,共4页 Jiangxi Medical Journal
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